BDBM274922 4-{[(3R,6R)-1-{[6-methoxy-2-(2H- 1,2,3-triazol-2-yl)pyridin-3- yl]carbonyl}-6-methylpiperidin-3- yl]oxy}-1,1-dimethylfuro[3,4- c]pyridin-3(1H)-one::US9556190, Example 12

SMILES COc1ccc(C(=O)N2C[C@@H](CC[C@H]2C)Oc2nccc3c2C(=O)OC3(C)C)c(n1)-n1nccn1

InChI Key InChIKey=ZKLYPGULKIBNLX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 274922   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM274922(4-{[(3R,6R)-1-{[6-methoxy-2-(2H- 1,2,3-triazol-2-y...)
Affinity DataIC50: 195nMAssay Description: In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
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TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM274922(4-{[(3R,6R)-1-{[6-methoxy-2-(2H- 1,2,3-triazol-2-y...)
Affinity DataIC50: 1.00E+4nMAssay Description: In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
Go to US Patent