BDBM27444 5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-3-[(4-methanesulfonylphenyl)methoxy]thiophene-2-carboxamide::BMCL191018 Compound 39::benzimidazole-thiophene carboxamide, 2

SMILES COc1cc2ncn(-c3cc(OCc4ccc(cc4)S(C)(=O)=O)c(s3)C(N)=O)c2cc1OC

InChI Key InChIKey=YYZTVTZCYVZGRB-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 27444   

LigandPNGBDBM27444(BMCL191018 Compound 39 | 5-(5,6-dimethoxy-1H-1,3-b...)
Affinity DataIC50: 75nMAssay Description:The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2009
Entry Details Article
PubMed
LigandPNGBDBM27444(BMCL191018 Compound 39 | 5-(5,6-dimethoxy-1H-1,3-b...)
Affinity DataIC50: 1.58E+4nMpH: 7.4 T: 2°CAssay Description:IKK kinase activity was assessed using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The reaction was initiated by the addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2009
Entry Details Article
PubMed
LigandPNGBDBM27444(BMCL191018 Compound 39 | 5-(5,6-dimethoxy-1H-1,3-b...)
Affinity DataIC50: 1.58E+4nMpH: 7.4 T: 2°CAssay Description:IKK kinase activity was assessed using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The reaction was initiated by the addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2009
Entry Details Article
PubMed
LigandPNGBDBM27444(BMCL191018 Compound 39 | 5-(5,6-dimethoxy-1H-1,3-b...)
Affinity DataIC50: 126nMpH: 7.2 T: 2°CAssay Description:The compound inhibitory activity was determined by incubation with purified PLK1 and biotinylated peptide substrate in the presence ATP/[gamma-33P]AT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2009
Entry Details Article
PubMed