BDBM274304 1-(1-acetylazetidin-3-yl)-6-(4-chlorophenyl)-3-cyclopropyl-5-(3,7-dimethyl-3H-[1,2,3]triazolo[4,5-b]pyridin-5-yl)-5,6-dihydropyrrolo[3,4-b]pyrrol-4(1H)-one::US9550796, Example 105

SMILES CC(=O)N1CC(C1)n1cc(C2CC2)c2C(=O)N(C(c12)c1ccc(Cl)cc1)c1cc(C)c2nnn(C)c2n1

InChI Key InChIKey=NBJPFMDWXKYTQF-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 274304   

TargetBromodomain-containing protein 4 [44-477](Human)
Novartis

US Patent
LigandPNGBDBM274304(1-(1-acetylazetidin-3-yl)-6-(4-chlorophenyl)-3-cyc...)
Affinity DataIC50: 11nMpH: 7.5Assay Description:All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
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TargetBromodomain-containing protein 2 [60-463](Human)
Novartis

US Patent
LigandPNGBDBM274304(1-(1-acetylazetidin-3-yl)-6-(4-chlorophenyl)-3-cyc...)
Affinity DataIC50: 13nMpH: 7.5Assay Description:All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
Go to US Patent

TargetBromodomain-containing protein 3(Human)
Novartis

US Patent
LigandPNGBDBM274304(1-(1-acetylazetidin-3-yl)-6-(4-chlorophenyl)-3-cyc...)
Affinity DataIC50: 12nMpH: 7.5Assay Description:All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
Go to US Patent

TargetCREB-binding protein(Human)
Novartis

US Patent
LigandPNGBDBM274304(1-(1-acetylazetidin-3-yl)-6-(4-chlorophenyl)-3-cyc...)
Affinity DataIC50: 1.41E+4nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM274304(1-(1-acetylazetidin-3-yl)-6-(4-chlorophenyl)-3-cyc...)
Affinity DataIC50: 11nMAssay Description:Inhibition of His-tagged BRD4 (44 to 477 residues) (unknown origin) using acetyl-histone H4 as substrate after 35 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2020
Entry Details Article
PubMed