BDBM27401 1-(2-hydroxyethyl)-2-(pyridin-4-yl)-1H,4H,5H,6H,7H-pyrrolo[3,2-c]pyridin-4-one::pyrrolopyridinone scaffold, 23

SMILES OCCn1c2CCNC(=O)c2cc1-c1ccncc1

InChI Key InChIKey=LWFINZKGSCYRMI-UHFFFAOYSA-N

Data  2 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 27401   

LigandPNGBDBM27401(1-(2-hydroxyethyl)-2-(pyridin-4-yl)-1H,4H,5H,6H,7H...)
Affinity DataIC50: 3.30E+3nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase N2(Human)
University of Sussex

Curated by ChEMBL
LigandPNGBDBM27401(1-(2-hydroxyethyl)-2-(pyridin-4-yl)-1H,4H,5H,6H,7H...)
Affinity DataIC50: 30nMAssay Description:Inhibition of PKN2 (unknown origin) by TR-FRET-based tracer displacement assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSerine/threonine-protein kinase N1(Human)
University of Sussex

Curated by ChEMBL
LigandPNGBDBM27401(1-(2-hydroxyethyl)-2-(pyridin-4-yl)-1H,4H,5H,6H,7H...)
Affinity DataIC50: 440nMAssay Description:Inhibition of PKN1 (unknown origin) by TR-FRET-based tracer displacement assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSerine/threonine-protein kinase N2(Human)
University of Sussex

Curated by ChEMBL
LigandPNGBDBM27401(1-(2-hydroxyethyl)-2-(pyridin-4-yl)-1H,4H,5H,6H,7H...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of NanoLuc-PKN2 (ser646-cys984)(unknown origin) expressed in HEK293 cells by cell-based NanoBRET target engagement assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSerine/threonine-protein kinase N2(Human)
University of Sussex

Curated by ChEMBL
LigandPNGBDBM27401(1-(2-hydroxyethyl)-2-(pyridin-4-yl)-1H,4H,5H,6H,7H...)
Affinity DataKi:  15nMAssay Description:Inhibition of PKN2 (unknown origin) by TR-FRET-based tracer displacement assay dependent Cheng-Prusoff equation analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSerine/threonine-protein kinase N1(Human)
University of Sussex

Curated by ChEMBL
LigandPNGBDBM27401(1-(2-hydroxyethyl)-2-(pyridin-4-yl)-1H,4H,5H,6H,7H...)
Affinity DataKi:  220nMAssay Description:Inhibition of PKN1 (unknown origin) by TR-FRET-based tracer displacement assay dependent Cheng-Prusoff equation analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed