BDBM273011 (R)-2-{6-methyl-5-[(morpholin-4-yl)methyl]-7-oxo-6,7-dihydro[1,3]thiazolo[5,4-d]pyrimidin-2-yl}pyrrolidine-1-carboxylic acid benzyl ester::US10065972, Example 8

SMILES Cn1c(CN2CCOCC2)nc2sc(nc2c1=O)[C@H]1CCCN1C(=O)OCc1ccccc1

InChI Key InChIKey=VQLPBLOZTCZMBE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 273011   

TargetKynurenine/alpha-aminoadipate aminotransferase, mitochondrial(Human)
Mitsubishi Tanabe Pharma

US Patent
LigandPNGBDBM273011((R)-2-{6-methyl-5-[(morpholin-4-yl)methyl]-7-oxo-6...)
Affinity DataIC50: 610nMpH: 8.0Assay Description:The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
Go to US Patent

TargetKynurenine/alpha-aminoadipate aminotransferase, mitochondrial(Human)
Mitsubishi Tanabe Pharma

US Patent
LigandPNGBDBM273011((R)-2-{6-methyl-5-[(morpholin-4-yl)methyl]-7-oxo-6...)
Affinity DataIC50: 610nMAssay Description:Inhibition of His-tagged recombinant human KATIIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed