BDBM272564 (R)-4-methyl-2-(8-methyl- 5,6,7,8-tetrahydro- [1,2,4]triazolo[4,3-a]pyrazin- 3-yl)oxazole::US10065961, Compound 27::US10941151, Compound 27

SMILES C[C@H]1NCCn2c1nnc2-c1nc(C)co1

InChI Key InChIKey=ZJUWQZAEPLRGCJ-UHFFFAOYSA-N

Data  2 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 272564   

TargetNeuromedin-K receptor(Human)
Ogeda

US Patent
LigandPNGBDBM272564((R)-4-methyl-2-(8-methyl- 5,6,7,8-tetrahydro- [1,2...)
Affinity DataIC50: 51nMAssay Description:The antagonist activity of compounds of the invention is measured following pre-incubation (3 minutes) of the compound with the cells, followed by ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
Go to US Patent

TargetNeuromedin-K receptor(Human)
Ogeda

US Patent
LigandPNGBDBM272564((R)-4-methyl-2-(8-methyl- 5,6,7,8-tetrahydro- [1,2...)
Affinity DataKi:  51nMAssay Description:The antagonist activity of compounds of the invention is measured following pre-incubation (3 minutes) of the compound with the cells, followed by ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
Go to US Patent

TargetNeuromedin-K receptor(Human)
Ogeda

US Patent
LigandPNGBDBM272564((R)-4-methyl-2-(8-methyl- 5,6,7,8-tetrahydro- [1,2...)
Affinity DataKi:  51nMAssay Description:NK3: The ability of compounds of the invention to inhibit the binding of the NK-3 receptor selective antagonist 3H-SB222200 was assessed by an in vit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2021
Entry Details
Go to US Patent