BDBM27188 triazole-linked clarithromycin-based compound, 24d

SMILES CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)Cc2ccc(cc2)-c2cn(CCCCCCC(=O)NO)nn2)[C@@](C)(C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O)OC

InChI Key InChIKey=OBRCETUNWRJYOJ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 27188   

TargetHistone deacetylase 1(Human)
Georgia Institute of Technology

LigandPNGBDBM27188(triazole-linked clarithromycin-based compound, 24d)
Affinity DataIC50: 1.90nMpH: 8.0 T: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2009
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
Georgia Institute of Technology

LigandPNGBDBM27188(triazole-linked clarithromycin-based compound, 24d)
Affinity DataIC50: 1.39E+3nMT: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2009
Entry Details Article
PubMed
TargetHistone deacetylase (HDAC1 and HDAC2)(Human)
Adam Mickiewicz University

Curated by ChEMBL
LigandPNGBDBM27188(triazole-linked clarithromycin-based compound, 24d)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of HDAC1/2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
Georgia Institute of Technology

LigandPNGBDBM27188(triazole-linked clarithromycin-based compound, 24d)
Affinity DataIC50: 1.39E+3nMAssay Description:Inhibition of HDAC8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed