BDBM2718 US8524710, 78::US8524710, 85::US8524710, 86

SMILES CC(CNC(=O)c1cnc(nc1N1CC[C@@H](C1)S(=O)(=O)c1ccccc1C(F)(F)F)C#N)c1ccc(Cl)cc1

InChI Key InChIKey=UJVPLWXQGKXZSK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 2718   

TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM2718(US8524710, 85 | US8524710, 86 | US8524710, 78)
Affinity DataIC50: 0.0560nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2013
Entry Details
Go to US Patent

TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM2718(US8524710, 85 | US8524710, 86 | US8524710, 78)
Affinity DataIC50: 0.365nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2013
Entry Details
Go to US Patent

TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM2718(US8524710, 85 | US8524710, 86 | US8524710, 78)
Affinity DataIC50: 31nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2013
Entry Details
Go to US Patent