BDBM270551 N-(3-((2R,3S,5R)-6-amino-3,5-difluoro-2,5-dimethyl-2,3,4,5-tetrahydropyridin-2-yl)-4-fluorophenyl)-5-methoxypicolinamide::US10059669, Compound 7::US10059669, Compound 8

SMILES COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@@]1(C)N=C(N)[C@](C)(F)C[C@@H]1F

InChI Key InChIKey=SDCQRHRAPZSMRH-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 270551   

TargetBeta-secretase 1(Human)
H. Lundbeck

US Patent
LigandPNGBDBM270551(N-(3-((2R,3S,5R)-6-amino-3,5-difluoro-2,5-dimethyl...)
Affinity DataKi:  39nM ΔG°:  -10.1kcal/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBeta-secretase 1(Human)
H. Lundbeck

US Patent
LigandPNGBDBM270551(N-(3-((2R,3S,5R)-6-amino-3,5-difluoro-2,5-dimethyl...)
Affinity DataKi:  58nM ΔG°:  -9.87kcal/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
In DepthDetails
US Patent