BDBM269508 US10058550, Example 27.0::US10058550, Example 549.0::US10221162, Example 38.0::US9845310, Example 43.0::yl)-1-methoxy-1-(5-methyl-2-pyrimidinyl)-2-propanesulfonamide

SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1

InChI Key InChIKey=RZJCKIXEYMQFPY-UHFFFAOYSA-N

Data  13 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 269508   

TargetApelin receptor(Human)
Amgen

US Patent
LigandPNGBDBM269508(US10058550, Example 549.0 | yl)-1-methoxy-1-(5-met...)
Affinity DataEC50:  0.190nMpH: 7.5Assay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV -3 expression vector (Si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
Go to US Patent

TargetApelin receptor(Human)
Amgen

US Patent
LigandPNGBDBM269508(US10058550, Example 549.0 | yl)-1-methoxy-1-(5-met...)
Affinity DataEC50:  0.190nMpH: 7.5Assay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV -3 expression vector (Si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
Go to US Patent

TargetApelin receptor(Human)
Amgen

US Patent
LigandPNGBDBM269508(US10058550, Example 549.0 | yl)-1-methoxy-1-(5-met...)
Affinity DataEC50:  0.190nMpH: 7.5Assay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV -3 expression vector (Si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
Go to US Patent

TargetApelin receptor(Human)
Amgen

US Patent
LigandPNGBDBM269508(US10058550, Example 549.0 | yl)-1-methoxy-1-(5-met...)
Affinity DataEC50:  0.190nMpH: 7.5Assay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV -3 expression vector (Si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
Go to US Patent

TargetApelin receptor(Human)
Amgen

US Patent
LigandPNGBDBM269508(US10058550, Example 549.0 | yl)-1-methoxy-1-(5-met...)
Affinity DataEC50:  0.190nMAssay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV -3 expression vector (Si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
Go to US Patent

TargetApelin receptor(Human)
Amgen

US Patent
LigandPNGBDBM269508(US10058550, Example 549.0 | yl)-1-methoxy-1-(5-met...)
Affinity DataEC50:  0.280nMAssay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV -3 expression vector (Si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
Go to US Patent

TargetApelin receptor(Human)
Amgen

US Patent
LigandPNGBDBM269508(US10058550, Example 549.0 | yl)-1-methoxy-1-(5-met...)
Affinity DataEC50:  0.180nMAssay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV -3 expression vector (Si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
Go to US Patent

TargetApelin receptor(Human)
Amgen

US Patent
LigandPNGBDBM269508(US10058550, Example 549.0 | yl)-1-methoxy-1-(5-met...)
Affinity DataEC50:  0.140nMAssay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV -3 expression vector (Si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
Go to US Patent

TargetApelin receptor(Human)
Amgen

US Patent
LigandPNGBDBM269508(US10058550, Example 549.0 | yl)-1-methoxy-1-(5-met...)
Affinity DataEC50:  0.190nMAssay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV -3 expression vector (Si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
Go to US Patent

TargetApelin receptor(Human)
Amgen

US Patent
LigandPNGBDBM269508(US10058550, Example 549.0 | yl)-1-methoxy-1-(5-met...)
Affinity DataEC50:  0.280nMAssay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2019
Entry Details
Go to US Patent

TargetApelin receptor(Human)
Amgen

US Patent
LigandPNGBDBM269508(US10058550, Example 549.0 | yl)-1-methoxy-1-(5-met...)
Affinity DataEC50:  0.180nMAssay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2019
Entry Details
Go to US Patent

TargetApelin receptor(Human)
Amgen

US Patent
LigandPNGBDBM269508(US10058550, Example 549.0 | yl)-1-methoxy-1-(5-met...)
Affinity DataEC50:  0.140nMAssay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2019
Entry Details
Go to US Patent

TargetApelin receptor(Human)
Amgen

US Patent
LigandPNGBDBM269508(US10058550, Example 549.0 | yl)-1-methoxy-1-(5-met...)
Affinity DataEC50:  0.470nMAssay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2019
Entry Details
Go to US Patent