BDBM267956 4-(8-amino-3-{4-[(1-cyanocyclopropyl)carbonyl]-1,1-dioxidothiomorpholin-2-yl}imidazo[1,5-a]pyrazin-1-yl)-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide::US9718828, Example, 572

SMILES COCCC(=O)N1CCSC(C1)c1nc(-c2ccc(cc2)C(=O)Nc2cc(ccn2)C(F)(F)F)c2c(N)nccn12

InChI Key InChIKey=MMUUBQDBHIQDCJ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 267956   

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267956(4-(8-amino-3-{4-[(1-cyanocyclopropyl)carbonyl]-1,1...)
Affinity DataIC50: 550nMpH: 7.2Assay Description:BTK enzymatic activity was determined in an IMAP-FP assay (Immobilized Metal ion Affinity-based fluorescence Polarization; Molecular Devices). Using ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267956(4-(8-amino-3-{4-[(1-cyanocyclopropyl)carbonyl]-1,1...)
Affinity DataIC50: 6.60nMAssay Description:Inhibition of recombinant full-length His6-tagged BTK (unknown origin) expressed in baculovirus infected Sf9 cells using biotinylated A5 peptide as s...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM267956(4-(8-amino-3-{4-[(1-cyanocyclopropyl)carbonyl]-1,1...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of human ERG by [35S]-MK499 displacement or iKr channel assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed