BDBM26564 (3R,4R)-3-N-hydroxy-4-N-{4-[(2-methyl-1-benzofuran-3-yl)methyl]benzene}oxane-3,4-dicarboxamide::2-methylbenzofuran, 25

SMILES Cc1oc2ccccc2c1Cc1ccc(cc1)C(=O)N[C@@H]1CCOC[C@@H]1C(=O)NO

InChI Key InChIKey=AXERWECZRIZWCH-UHFFFAOYSA-N

Data  4 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 26564   

LigandPNGBDBM26564((3R,4R)-3-N-hydroxy-4-N-{4-[(2-methyl-1-benzofuran...)
Affinity DataIC50: 1.60nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/26/2009
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Bristol-Myers Squibb

LigandPNGBDBM26564((3R,4R)-3-N-hydroxy-4-N-{4-[(2-methyl-1-benzofuran...)
Affinity DataKi:  53nMAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/26/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Bristol-Myers Squibb

LigandPNGBDBM26564((3R,4R)-3-N-hydroxy-4-N-{4-[(2-methyl-1-benzofuran...)
Affinity DataKi:  1.12E+3nMAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/26/2009
Entry Details Article
PubMed
TargetMatrilysin(Human)
Bristol-Myers Squibb

LigandPNGBDBM26564((3R,4R)-3-N-hydroxy-4-N-{4-[(2-methyl-1-benzofuran...)
Affinity DataKi:  3.31E+3nMAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/26/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Bristol-Myers Squibb

LigandPNGBDBM26564((3R,4R)-3-N-hydroxy-4-N-{4-[(2-methyl-1-benzofuran...)
Affinity DataKi: >3.33E+3nM ΔG°: >-7.47kcal/molepH: 7.5 T: 2°CAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/26/2009
Entry Details Article
PubMed