BDBM264172 (E)-N-(7-(((S)-1,4-dioxan-2-yl)methoxy)-4-(3-chloro-4-fluorophenylamino)quinazolin-6-yl)-4-(2-(hydroxymethyl)azetidin-1-yl)but-2-enamide::US9714235, 16

SMILES OCC1CCN1C\C=C\C(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1OC[C@@H]1COCCO1

InChI Key InChIKey=QJNMNCUMDUMIJV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 264172   

TargetEpidermal growth factor receptor(Human)
Shanghai Fochon Pharmaceutical

US Patent
LigandPNGBDBM264172((E)-N-(7-(((S)-1,4-dioxan-2-yl)methoxy)-4-(3-chlor...)
Affinity DataIC50: 17.5nMAssay Description:To investigate whether a compound is able to inhibit the activity of EGFR and ErbB2 in cells, a mechanism-based assay using BT474 (EGFR overexpressio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
Go to US Patent

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Shanghai Fochon Pharmaceutical

US Patent
LigandPNGBDBM264172((E)-N-(7-(((S)-1,4-dioxan-2-yl)methoxy)-4-(3-chlor...)
Affinity DataIC50: 39.5nMAssay Description:To investigate whether a compound is able to inhibit the activity of EGFR and ErbB2 in cells, a mechanism-based assay using BT474 (EGFR overexpressio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
Go to US Patent