BDBM264161 (S,E)-N-(4-(3-chloro-4-fluorophenylamino)-7-ethoxyquinazolin-6-yl)-4-(2-(methoxymethyl)azetidin-1-yl)but-2-enamide::US9714235, 5

SMILES CCOc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)\C=C\CN1CC[C@H]1COC

InChI Key InChIKey=YFFQYUIFTHZMHX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 264161   

TargetEpidermal growth factor receptor(Human)
Shanghai Fochon Pharmaceutical

US Patent
LigandPNGBDBM264161((S,E)-N-(4-(3-chloro-4-fluorophenylamino)-7-ethoxy...)
Affinity DataIC50: 7.80nMAssay Description:To investigate whether a compound is able to inhibit the activity of EGFR and ErbB2 in cells, a mechanism-based assay using BT474 (EGFR overexpressio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
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TargetReceptor tyrosine-protein kinase erbB-2(Human)
Shanghai Fochon Pharmaceutical

US Patent
LigandPNGBDBM264161((S,E)-N-(4-(3-chloro-4-fluorophenylamino)-7-ethoxy...)
Affinity DataIC50: 8.10nMAssay Description:To investigate whether a compound is able to inhibit the activity of EGFR and ErbB2 in cells, a mechanism-based assay using BT474 (EGFR overexpressio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
Go to US Patent