BDBM264128 (E)-N-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl)-4-(2-(hydroxymethyl)azetidin-1-yl)but-2-enamide::US9714235, 1

SMILES COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)\C=C\CN1CCC1CO

InChI Key InChIKey=MCVGYROQTOADFC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 264128   

TargetEpidermal growth factor receptor(Human)
Shanghai Fochon Pharmaceutical

US Patent
LigandPNGBDBM264128((E)-N-(4-(3-chloro-4-fluorophenylamino)-7-methoxyq...)
Affinity DataIC50: 2.30nMAssay Description:To investigate whether a compound is able to inhibit the activity of EGFR and ErbB2 in cells, a mechanism-based assay using BT474 (EGFR overexpressio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
Go to US Patent

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Shanghai Fochon Pharmaceutical

US Patent
LigandPNGBDBM264128((E)-N-(4-(3-chloro-4-fluorophenylamino)-7-methoxyq...)
Affinity DataIC50: 5nMAssay Description:To investigate whether a compound is able to inhibit the activity of EGFR and ErbB2 in cells, a mechanism-based assay using BT474 (EGFR overexpressio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
Go to US Patent