BDBM263986 2-{5-[(1-methyl-1H-indazol-6- yl)methoxy]-1H-pyrazol-1- yl}pyridine-4-carboxylic acid::US9604961, Example 51::US9714230, 51::US9908865, Example 51

SMILES Cn1cc2ccc(COc3ccnn3-c3cc(ccn3)C(O)=O)cc2n1

InChI Key InChIKey=KPTQBEMJSNBGAL-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 263986   

TargetLysine-specific demethylase 5A(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM263986(2-{5-[(1-methyl-1H-indazol-6- yl)methoxy]-1H-pyraz...)
Affinity DataIC50: 100nMAssay Description:The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2020
Entry Details
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TargetLysine-specific demethylase 5B(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM263986(2-{5-[(1-methyl-1H-indazol-6- yl)methoxy]-1H-pyraz...)
Affinity DataIC50: 100nMAssay Description:The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2020
Entry Details
Go to US Patent

TargetLysine-specific demethylase 4C(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM263986(2-{5-[(1-methyl-1H-indazol-6- yl)methoxy]-1H-pyraz...)
Affinity DataIC50: 550nMAssay Description:The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2020
Entry Details
Go to US Patent