BDBM263920 6-(2- Chloro-3- fluoro- phenyl)-5- {4-[(S)-1- (3-fluoro- propyl)- pyrrolidin-3- yloxy]- phenyl}-8,9- dihydro- 7H- benzocyclo- heptene-2- carboxylic acid::US9714221, Example 216

SMILES OC(=O)c1ccc2c(CCCC(c3cccc(F)c3Cl)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1

InChI Key InChIKey=DOHXNJZDPZLWAD-UHFFFAOYSA-N

Data  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 263920   

TargetEstrogen receptor(Human)
Sanofi

US Patent
LigandPNGBDBM263920(6-(2- Chloro-3- fluoro- phenyl)-5- {4-[(S)-1- (3-f...)
Affinity DataIC50: 39nMpH: 7.4 T: 2°CAssay Description:It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
Go to US Patent

TargetEstrogen receptor [D538G](Human)
Sanofi

US Patent
LigandPNGBDBM263920(6-(2- Chloro-3- fluoro- phenyl)-5- {4-[(S)-1- (3-f...)
Affinity DataIC50: 960nMpH: 7.4 T: 2°CAssay Description:It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
Go to US Patent

TargetEstrogen receptor [Y537S](Human)
Sanofi

US Patent
LigandPNGBDBM263920(6-(2- Chloro-3- fluoro- phenyl)-5- {4-[(S)-1- (3-f...)
Affinity DataIC50: 632nMpH: 7.4 T: 2°CAssay Description:It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Sanofi

US Patent
LigandPNGBDBM263920(6-(2- Chloro-3- fluoro- phenyl)-5- {4-[(S)-1- (3-f...)
Affinity DataEC50:  3nMAssay Description:Induction of ERalpha degradation in human MCF7 cells incubated for 4 hrs by Alexafluor-488 conjugate anti-rabbit antibody/Syto-64 staining based immu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed