BDBM263503 (s)-n-(1-(2-fluoro-4-(trifluoromethoxy)phenyl)ethyl)-2-(6-fluoro-4-oxobenzo[d][1,2,3]triazin-3(4h)-yl)acetamide::US10561662, Example 71::US11173161, EX 71::US9556130, test 71

SMILES C[C@H](NC(=O)Cn1nnc2ccc(F)cc2c1=O)c1ccc(OC(F)(F)F)cc1F

InChI Key InChIKey=RXHUKMCACHRXDL-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 263503   

TargetProbable G-protein coupled receptor 139(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM263503((s)-n-(1-(2-fluoro-4-(trifluoromethoxy)phenyl)ethy...)
Affinity DataKi:  93nM ΔG°:  -8.91kcal/molepH: 7.4 T: 2°CAssay Description:This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2018
Entry Details
Go to US Patent

TargetProbable G-protein coupled receptor 139(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM263503((s)-n-(1-(2-fluoro-4-(trifluoromethoxy)phenyl)ethy...)
Affinity DataKi:  93nMAssay Description:Membranes were removed from −80° C., thawed and diluted in cold radioligand assay buffer (20 mM HEPES pH 7.4/5 mM MgCl2/1 mM CaCl2/Roche protea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent

TargetProbable G-protein coupled receptor 139(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM263503((s)-n-(1-(2-fluoro-4-(trifluoromethoxy)phenyl)ethy...)
Affinity DataKi:  9.30E+4nMAssay Description:This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
Go to US Patent