BDBM26121 SUCCINIC ACID::Substrate analogue, 11::Succinate::Succinic acid, 6::butanedioic acid::succinate, 9

SMILES OC(=O)CCC(O)=O

InChI Key InChIKey=KDYFGRWQOYBRFD-UHFFFAOYSA-N

Data  2 KI  15 IC50  3 Kd  1 ITC

PDB links: 329 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 26121   

TargetMethylcytosine dioxygenase TET1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM26121(Succinic acid, 6 | butanedioic acid | Succinate | ...)
Affinity DataIC50: 1.18E+5nMAssay Description:Inhibition of N-terminal 3xFlag-tagged human TET1 catalytic domain (E1418 to V2136 residues) expressed in Sf9 cells using 5-methylcytosine as substra...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific demethylase 5B(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM26121(Succinic acid, 6 | butanedioic acid | Succinate | ...)
Affinity DataIC50: 1.40E+6nMAssay Description:Inhibition of KDM5B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProlyl hydroxylase EGLN3(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM26121(Succinic acid, 6 | butanedioic acid | Succinate | ...)
Affinity DataIC50: 5.70E+5nMAssay Description:Inhibition of human PHD3 expressed in H5 insect cellsMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetEgl nine homolog 1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM26121(Succinic acid, 6 | butanedioic acid | Succinate | ...)
Affinity DataIC50: 5.10E+5nMAssay Description:Inhibition of human PHD2 expressed in H5 insect cellsMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProlyl hydroxylase EGLN2(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM26121(Succinic acid, 6 | butanedioic acid | Succinate | ...)
Affinity DataIC50: 8.30E+5nMAssay Description:Inhibition of human PHD1 expressed in H5 insect cellsMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHypoxia-inducible factor 1-alpha inhibitor(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM26121(Succinic acid, 6 | butanedioic acid | Succinate | ...)
Affinity DataIC50: 1.00E+7nMAssay Description:Inhibition of human FIH expressed in H5 insect cellsMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetRNA demethylase ALKBH5(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM26121(Succinic acid, 6 | butanedioic acid | Succinate | ...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant human ALKBH5 catalytic AlkB domain (74 to 294 residues) transfected in Escherichia coli BL21 (DE3) using 8-mer m6A-ssDNA as...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM26121(Succinic acid, 6 | butanedioic acid | Succinate | ...)
Affinity DataIC50: 3.70E+5nMAssay Description:Inhibition of FTO (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMethylcytosine dioxygenase TET3(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM26121(Succinic acid, 6 | butanedioic acid | Succinate | ...)
Affinity DataIC50: 1.18E+5nMAssay Description:Inhibition of human TET3 catalytic domain (E824 to I1795 residues) expressed in mammalian cells using 5-methylcytosine as substrate preincubated for ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMethylcytosine dioxygenase TET2(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM26121(Succinic acid, 6 | butanedioic acid | Succinate | ...)
Affinity DataIC50: 1.18E+5nMAssay Description:Inhibition of His10-FLAG tagged human TET2 catalytic domain (Q969 to I2002 residues) expressed in Sf9 cells using 5-methylcytosine as substrate prein...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific demethylase 4E(Human)
University of Oxford

LigandPNGBDBM26121(Succinic acid, 6 | butanedioic acid | Succinate | ...)
Affinity DataIC50: 7.10E+5nMpH: 7.5 T: 2°CAssay Description:A coupled-assay for JMJD2E activity employing formaldehyde dehydrogenase (FDH) from Pseudomonas putida was developed. Formaldehyde release by demethy...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 5B(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM26121(Succinic acid, 6 | butanedioic acid | Succinate | ...)
Affinity DataIC50: 1.40E+6nMAssay Description:Inhibition of KDM5B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProlyl 4-hydroxylase(PBCV-1)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM26121(Succinic acid, 6 | butanedioic acid | Succinate | ...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of N-terminal His6-tagged recombinant Paramecium bursaria chlorella virus 1 CPH expressed in Escherichia coli Rosetta 2 (DE3) cells pre-in...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEgl nine homolog 1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM26121(Succinic acid, 6 | butanedioic acid | Succinate | ...)
Affinity DataIC50: 1.00E+7nMAssay Description:Inhibition of PHD2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEgl nine homolog 1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM26121(Succinic acid, 6 | butanedioic acid | Succinate | ...)
Affinity DataKd: >1.00E+5nMAssay Description:Binding affinity to human PHD2 by nondenaturing ESI-MSMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEgl nine homolog 1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM26121(Succinic acid, 6 | butanedioic acid | Succinate | ...)
Affinity DataKd: >1.00E+5nMAssay Description:Binding affinity to human PHD2-Mn(II) using 12.5% H2O/87.5% D2O MQC spectrometer operated at 500 MHz at 298K temperatureMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEgl nine homolog 1(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM26121(Succinic acid, 6 | butanedioic acid | Succinate | ...)
Affinity DataIC50: 8.53E+4nMAssay Description:Inhibition of human PHD2 at 293K temperature by solvent relaxation techniqueMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMethyl-accepting chemotaxis protein NahY(Pseudomonas putida (g-Proteobacteria))
Csic

LigandPNGBDBM26121(Succinic acid, 6 | butanedioic acid | Succinate | ...)
Affinity DataKd:  8.20E+4nMT: 2°CAssay Description:Measurements were done on a VP-microcalorimeter (MicroCal, Amherst, MA).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetN(4)-(beta-N-acetylglucosaminyl)-L-asparaginase(Human)
University of North Carolina

LigandPNGBDBM26121(Succinic acid, 6 | butanedioic acid | Succinate | ...)
Affinity DataKi:  5.00E+6nM ΔG°:  -3.26kcal/molepH: 5.8 T: 2°CAssay Description:Glycosylasparaginase activity was measured in citrate-phosphate buffer at pH 5.8 at 37 C. N-Acetyl-D-glucosamine released during the reaction was me...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDelta-aminolevulinic acid dehydratase(Escherichia coli (strain K12))
University of NeuchÂTel

LigandPNGBDBM26121(Succinic acid, 6 | butanedioic acid | Succinate | ...)
Affinity DataKi:  1.25E+7nM ΔG°:  -2.70kcal/molepH: 8.1 T: 2°CAssay Description:The PBGS assay is a colorimetric assay based on the reaction between PBG and 4-dimethylaminobenzaldehyde (Ehrlich's reagent). More data for this Ligand-Target Pair
In DepthDetails Article
PubMed

Activity Spreadsheet -- ITC Data from BindingDB

Found 1 hit for monomerid = 26121   

CellMethyl-accepting chemotaxis protein (McpS)(Pseudomonas putida (g-Proteobacteria))
Csic

SyringePNGBDBM26121(Succinic acid, 6 | butanedioic acid | Succinate | ...)
ITC DataΔG°: -5.48kcal/mole −TΔS°: 4.90kcal/mole ΔH°: -10.2kcal/mole logk: 1.22E+4
T: 20.00°C 
In DepthDetails Article
PubMed