BDBM261168 5-(3-{1-[4-Amino-3-(difluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]ethyl}-5-chloro-2-methoxy-6-methylphenyl)-N,N-dimethylpyridine-2-carboxamide::US10092570, Example 191::US11433071, Example 191::US9707233, 191::US9730939, Example 191

SMILES COc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)C)C(C)Nc1ncnc(N)c1C(=N)C(F)F

InChI Key InChIKey=QMUKEAJHEZKJBD-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 261168   

LigandPNGBDBM261168(5-(3-{1-[4-Amino-3-(difluoromethyl)-1H-pyrazolo[3,...)
Affinity DataIC50: 10nMpH: 6.7 T: 2°CAssay Description:Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM261168(5-(3-{1-[4-Amino-3-(difluoromethyl)-1H-pyrazolo[3,...)
Affinity DataIC50: 10nMpH: 6.7 T: 2°CAssay Description:[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM261168(5-(3-{1-[4-Amino-3-(difluoromethyl)-1H-pyrazolo[3,...)
Affinity DataIC50: 10nMAssay Description:[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM261168(5-(3-{1-[4-Amino-3-(difluoromethyl)-1H-pyrazolo[3,...)
Affinity DataIC50: 10nMAssay Description:The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...More data for this Ligand-Target Pair
In DepthDetails
US Patent