BDBM259599 US9505749, 112

SMILES Clc1cccc(O[C@H]2CC[C@@H](CC2)NC(=O)CCSc2nc3ccccc3c(=O)[nH]2)c1

InChI Key InChIKey=HNNOUHLGNDSYMQ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 259599   

LigandPNGBDBM259599(US9505749, 112)
Affinity DataIC50: 0.224nMAssay Description:The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM259599(US9505749, 112)
Affinity DataIC50: 0.264nMAssay Description:The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Amgen

US Patent
LigandPNGBDBM259599(US9505749, 112)
Affinity DataIC50: 8.50E+4nMAssay Description:PARP1 biochemical assay was purchased as a kit from Trevigen (cat.#4676-096-K) and used per manufacturers recommendations.PARP2 biochemical assay was...More data for this Ligand-Target Pair
In DepthDetails
US Patent