BDBM258521 US10633384, Example 6::US9493486, 6

SMILES Clc1cc(Cl)cc(\C=C\C(=O)N2CCC3(CN(C3)C(=O)c3ccc4[nH]nnc4c3)CC2)c1

InChI Key InChIKey=CHMCNIRNOVQGFL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 258521   

TargetAutotaxin(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM258521(US9493486, 6 | US10633384, Example 6)
Affinity DataIC50: 26nMpH: 8.0 T: 2°CAssay Description:ATX inhibition was measured by a fluorescence quenching assay using a specifically labeled substrate analogue (MR121 substrate). To obtain this MR121...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
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TargetAutotaxin(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM258521(US9493486, 6 | US10633384, Example 6)
Affinity DataIC50: 26nMAssay Description:ATX inhibition was measured by a fluorescence quenching assay using a specifically labeled substrate analogue (MR121 substrate). To obtain this MR121...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2021
Entry Details
Go to US Patent