BDBM25849 4-[5-(4-hydroxyphenyl)thiophen-2-yl]phenol::CHEMBL204010::hydroxyphenyl substituted thiophene, 21

SMILES Oc1ccc(cc1)-c1ccc(s1)-c1ccc(O)cc1

InChI Key InChIKey=KZMOBYGIRBRCFV-UHFFFAOYSA-N

Data  1 KI  2 EC50  1 Other

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 25849   

Target17-beta-hydroxysteroid dehydrogenase type 1(Human)
Saarland University

LigandPNGBDBM25849(4-[5-(4-hydroxyphenyl)thiophen-2-yl]phenol | CHEMB...)
Affinity DatapH: 7.0 T: 2°CAssay Description:Tritiated E1 was incubated with 17beta-HSD1, cofactor, and inhibitor. The amount of labeled E2 formed was quantified by HPLC. Detection and quantific...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2008
Entry Details Article
PubMed
TargetEstrogen receptor beta(Human)
Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University)

Curated by ChEMBL
LigandPNGBDBM25849(4-[5-(4-hydroxyphenyl)thiophen-2-yl]phenol | CHEMB...)
Affinity DataEC50:  1.54E+3nMAssay Description:Agonist activity at estrogen receptor beta (unknown origin) expressed in human HepG2 cells coexpressing estrogen response element after 24 hrs by luc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University)

Curated by ChEMBL
LigandPNGBDBM25849(4-[5-(4-hydroxyphenyl)thiophen-2-yl]phenol | CHEMB...)
Affinity DataEC50:  2.35E+3nMAssay Description:Agonist activity at estrogen receptor alpha (unknown origin) expressed in human HepG2 cells coexpressing estrogen response element after 24 hrs by lu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM25849(4-[5-(4-hydroxyphenyl)thiophen-2-yl]phenol | CHEMB...)
Affinity DataKi:  4nMAssay Description:Displacement of [125I]IMPY from beta amyloid plaque in brain homogenatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed