BDBM258436 US9512082, 1

SMILES COc1ccc(NC(=O)NCCCn2cncc2C)cc1OC

InChI Key InChIKey=UXSPRKSPXIWEHE-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 258436   

TargetGlutaminyl-peptide cyclotransferase(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM258436(US9512082, 1)
Affinity DataIC50: 162nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged glutaminyl cyclase (Ala33 to Leu361 residues) expressed in baculovirus infected Sf21 insect ce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetGlutaminyl-peptide cyclotransferase(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM258436(US9512082, 1)
Affinity DataIC50: 162nMAssay Description:Inhibition of human recombinant glutaminyl cyclase using H-Gln-AMC hydrobromide as substrate measured after 15 mins by fluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetGlutaminyl-peptide cyclotransferase(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM258436(US9512082, 1)
Affinity DataKi:  31.2nM ΔG°:  -10.4kcal/mole IC50: 192nMpH: 8.0 T: 2°CAssay Description:For inhibitor testing, the sample composition was the same as described below, except of the putative inhibitory compound added. For a rapid test of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2017
Entry Details
Go to US Patent