BDBM258317 US9493485, 9-158

SMILES CC1(N=C(N)OC2(CCOCC2)C1(F)F)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F

InChI Key InChIKey=ICLVFRMEZOPZEF-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 258317   

TargetBeta-secretase 1(Human)
Imago Pharmaceuticals

US Patent
LigandPNGBDBM258317(US9493485, 9-158)
Affinity DataIC50: 15nMpH: 7.0Assay Description:BACE1 activity can be assessed in an AlphaScreen assay. Compounds to be assessed (e.g. compounds as described in the above examples) are serially dil...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBeta-secretase 1(Human)
Imago Pharmaceuticals

US Patent
LigandPNGBDBM258317(US9493485, 9-158)
Affinity DataIC50: 94nMpH: 4.5 T: 2°CAssay Description:Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCathepsin D(Human)
Imago Pharmaceuticals

US Patent
LigandPNGBDBM258317(US9493485, 9-158)
Affinity DataIC50: 1.96E+4nMpH: 4.5 T: 2°CAssay Description:Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...More data for this Ligand-Target Pair
In DepthDetails
US Patent