BDBM258146 US9493448, 122::US9493448, 154::US9493448, 48::US9597330, Example 34::US9845313, Example 154

SMILES Cn1nccc1[C@H]1CCCC[C@@H]1Oc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccncn1

InChI Key InChIKey=OJKONCJPCULNOW-UHFFFAOYSA-N

Data  32 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 32 hits for monomerid = 258146   

LigandPNGBDBM258146(US9493448, 48 | US9493448, 122 | US9493448, 154 | ...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human ERG by Ionworks high-throughput electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM258146(US9493448, 48 | US9493448, 122 | US9493448, 154 | ...)
Affinity DataIC50: 8.70E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM258146(US9493448, 48 | US9493448, 122 | US9493448, 154 | ...)
Affinity DataIC50: 4.90E+3nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
LigandPNGBDBM258146(US9493448, 48 | US9493448, 122 | US9493448, 154 | ...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human ERG expressed in HEK293 cells with -80 mV holding potential by whole cell manual patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetSodium channel subunit beta-2(Mouse)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM258146(US9493448, 48 | US9493448, 122 | US9493448, 154 | ...)
Affinity DataIC50: 59nMAssay Description:Inhibition of mouse Nav1.7/beta1/beta2 expressed in HEK293A cells with -120 mV holding potential by whole cell manual patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
LigandPNGBDBM258146(US9493448, 48 | US9493448, 122 | US9493448, 154 | ...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of mouse Nav1.5/beta1/beta2 expressed in HEK293A cells with -140 mV holding potential by whole cell manual patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
LigandPNGBDBM258146(US9493448, 48 | US9493448, 122 | US9493448, 154 | ...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of mouse Nav1.1/beta1/beta2 expressed in HEK293A cells with -120 mV holding potential by whole cell manual patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM258146(US9493448, 48 | US9493448, 122 | US9493448, 154 | ...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human Nav1.8 expressed in ND7/23 cells with -120 mV holding potential by whole cell manual patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM258146(US9493448, 48 | US9493448, 122 | US9493448, 154 | ...)
Affinity DataIC50: 23nMAssay Description:Inhibition of human Nav1.7 expressed in CHO cells with -120 mV holding potential by whole cell manual patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetSodium channel protein type 8 subunit alpha(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM258146(US9493448, 48 | US9493448, 122 | US9493448, 154 | ...)
Affinity DataIC50: 475nMAssay Description:Inhibition of human Nav1.6 expressed in CHO cells with -120 mV holding potential by whole cell manual patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM258146(US9493448, 48 | US9493448, 122 | US9493448, 154 | ...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human Nav1.5 expressed in CHO cells with -140 mV holding potential by whole cell manual patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
LigandPNGBDBM258146(US9493448, 48 | US9493448, 122 | US9493448, 154 | ...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human Nav1.4/beta1/beta2 expressed in CHO cells with -120 mV holding potential by whole cell manual patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetSodium channel protein type 3 subunit alpha(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM258146(US9493448, 48 | US9493448, 122 | US9493448, 154 | ...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human Nav1.3 expressed in CHO cells with -120 mV holding potential by whole cell manual patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetSodium channel protein type 2 subunit alpha(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM258146(US9493448, 48 | US9493448, 122 | US9493448, 154 | ...)
Affinity DataIC50: 1.96E+3nMAssay Description:Inhibition of human Nav1.2 expressed in CHO cells with -120 mV holding potential by whole cell manual patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetSodium channel protein type 1 subunit alpha(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM258146(US9493448, 48 | US9493448, 122 | US9493448, 154 | ...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human Nav1.1 expressed in CHO cells with -120 mV holding potential by whole cell manual patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
LigandPNGBDBM258146(US9493448, 48 | US9493448, 122 | US9493448, 154 | ...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human ERG by Ionworks high-throughput electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM258146(US9493448, 48 | US9493448, 122 | US9493448, 154 | ...)
Affinity DataIC50: 16nMpH: 7.3 T: 2°CAssay Description:Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2017
Entry Details
Go to US Patent

TargetSodium channel subunit beta-2(Mouse)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM258146(US9493448, 48 | US9493448, 122 | US9493448, 154 | ...)
Affinity DataIC50: 26.5nMAssay Description:Inhibition of mouse NaV1.7/beta1/beta2 expressed in HEK293A cells by Ionworks high-throughput electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetSodium channel subunit beta-2(Mouse)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM258146(US9493448, 48 | US9493448, 122 | US9493448, 154 | ...)
Affinity DataIC50: 27nMAssay Description:Inhibition of mouse NaV1.7/beta1/beta2 expressed in HEK293A cells by Ionworks high-throughput electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetSodium channel subunit beta-2(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM258146(US9493448, 48 | US9493448, 122 | US9493448, 154 | ...)
Affinity DataIC50: 24.5nMAssay Description:Inhibition of human NaV1.7/beta1/beta2 expressed in HEK293A cells by Ionworks high-throughput electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetSodium channel subunit beta-2(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM258146(US9493448, 48 | US9493448, 122 | US9493448, 154 | ...)
Affinity DataIC50: 25nMAssay Description:Inhibition of human NaV1.7/beta1/beta2 expressed in HEK293A cells by Ionworks high-throughput electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
LigandPNGBDBM258146(US9493448, 48 | US9493448, 122 | US9493448, 154 | ...)
Affinity DataIC50: 9.30E+4nMAssay Description:Inhibition of human NaV1.5/beta1/beta2 expressed in HEK293A cells by Ionworks high-throughput electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
LigandPNGBDBM258146(US9493448, 48 | US9493448, 122 | US9493448, 154 | ...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human NaV1.5/beta1/beta2 expressed in HEK293A cells by Ionworks high-throughput electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
LigandPNGBDBM258146(US9493448, 48 | US9493448, 122 | US9493448, 154 | ...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human NaV1.1/beta1/beta2 expressed in HEK293A cells by Ionworks high-throughput electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
LigandPNGBDBM258146(US9493448, 48 | US9493448, 122 | US9493448, 154 | ...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human NaV1.1/beta1/beta2 expressed in HEK293A cells by Ionworks high-throughput electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM258146(US9493448, 48 | US9493448, 122 | US9493448, 154 | ...)
Affinity DataIC50: 17nMAssay Description:Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2019
Entry Details
Go to US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM258146(US9493448, 48 | US9493448, 122 | US9493448, 154 | ...)
Affinity DataIC50: 20nMAssay Description:Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2019
Entry Details
Go to US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM258146(US9493448, 48 | US9493448, 122 | US9493448, 154 | ...)
Affinity DataIC50: 16nMAssay Description:Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2019
Entry Details
Go to US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM258146(US9493448, 48 | US9493448, 122 | US9493448, 154 | ...)
Affinity DataIC50: 20nMAssay Description:Current recording was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
Go to US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM258146(US9493448, 48 | US9493448, 122 | US9493448, 154 | ...)
Affinity DataIC50: 16nMAssay Description:Current recording was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
Go to US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM258146(US9493448, 48 | US9493448, 122 | US9493448, 154 | ...)
Affinity DataIC50: 17nMpH: 7.3 T: 2°CAssay Description:Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2017
Entry Details
Go to US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM258146(US9493448, 48 | US9493448, 122 | US9493448, 154 | ...)
Affinity DataIC50: 20nMpH: 7.3 T: 2°CAssay Description:Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2017
Entry Details
Go to US Patent