BDBM258144 US9493448, 46::US9597330, Example 11::US9845313, Example 46

SMILES Cn1nccc1[C@H]1CCCC[C@@H]1Oc1cc(F)c(c(F)c1)S(=O)(=O)Nc1ccncn1

InChI Key InChIKey=PDNOJYMMZNQRJD-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 258144   

TargetSodium channel protein type 9 subunit alpha(Human)
Daiichi Sankyo

US Patent
LigandPNGBDBM258144(US9493448, 46 | US9597330, Example 11 | US9845313,...)
Affinity DataIC50: 30nMpH: 7.3 T: 2°CAssay Description:Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2017
Entry Details
Go to US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Daiichi Sankyo

US Patent
LigandPNGBDBM258144(US9493448, 46 | US9597330, Example 11 | US9845313,...)
Affinity DataIC50: 30nMAssay Description:Current recording was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
Go to US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Daiichi Sankyo

US Patent
LigandPNGBDBM258144(US9493448, 46 | US9597330, Example 11 | US9845313,...)
Affinity DataIC50: 30nMAssay Description:Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2019
Entry Details
Go to US Patent

LigandPNGBDBM258144(US9493448, 46 | US9597330, Example 11 | US9845313,...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human NaV1.1/beta1/beta2 expressed in HEK293A cells by Ionworks high-throughput electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
LigandPNGBDBM258144(US9493448, 46 | US9597330, Example 11 | US9845313,...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human NaV1.5/beta1/beta2 expressed in HEK293A cells by Ionworks high-throughput electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetSodium channel subunit beta-2(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM258144(US9493448, 46 | US9597330, Example 11 | US9845313,...)
Affinity DataIC50: 30nMAssay Description:Inhibition of human NaV1.7/beta1/beta2 expressed in HEK293A cells by Ionworks high-throughput electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetSodium channel subunit beta-2(Mouse)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM258144(US9493448, 46 | US9597330, Example 11 | US9845313,...)
Affinity DataIC50: 56nMAssay Description:Inhibition of mouse NaV1.7/beta1/beta2 expressed in HEK293A cells by Ionworks high-throughput electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
LigandPNGBDBM258144(US9493448, 46 | US9597330, Example 11 | US9845313,...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human ERG by Ionworks high-throughput electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed