BDBM25741 4-{[4-({[4-(trifluoromethoxy)phenyl]carbamoyl}amino)cyclohexyl]oxy}benzoic acid::US10383835, Compound 1728::Urea-based compound, 22

SMILES OC(=O)c1ccc(OC2CCC(CC2)NC(=O)Nc2ccc(OC(F)(F)F)cc2)cc1

InChI Key InChIKey=XDVFKCZZXOGEMN-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 25741   

TargetEpoxide hydrolase B(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
University of Alberta

LigandPNGBDBM25741(4-{[4-({[4-(trifluoromethoxy)phenyl]carbamoyl}amin...)
Affinity DataIC50: 1.21E+4nMpH: 7.0 T: 2°CAssay Description:Enzyme activity was measured by monitoring the appearance of fluorescent product, 6-methoxy-naphthaldehyde (ex@330 nm and em@ 465 nm) on a SpectraMax...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM25741(4-{[4-({[4-(trifluoromethoxy)phenyl]carbamoyl}amin...)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of human recombinant soluble epoxide hydrolase assessed as cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxyran-2-yl)methyl] carb...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEpoxide hydrolase(Horse)
The Regents of The University of California

US Patent
LigandPNGBDBM25741(4-{[4-({[4-(trifluoromethoxy)phenyl]carbamoyl}amin...)
Affinity DataIC50: 3nMAssay Description:The enzyme also can be detected based on the binding of specific ligands to the catalytic site which either immobilize the enzyme or label it with a ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetEpoxide hydrolase(Sheep)
The Regents of The University of California

US Patent
LigandPNGBDBM25741(4-{[4-({[4-(trifluoromethoxy)phenyl]carbamoyl}amin...)
Affinity DataIC50: 1nMAssay Description:The enzyme also can be detected based on the binding of specific ligands to the catalytic site which either immobilize the enzyme or label it with a ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBifunctional epoxide hydrolase 2(Pig)
The Regents of The University of California

US Patent
LigandPNGBDBM25741(4-{[4-({[4-(trifluoromethoxy)phenyl]carbamoyl}amin...)
Affinity DataIC50: 12nMAssay Description:The enzyme also can be detected based on the binding of specific ligands to the catalytic site which either immobilize the enzyme or label it with a ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetEpoxide hydrolase 1(Cat)
The Regents of The University of California

US Patent
LigandPNGBDBM25741(4-{[4-({[4-(trifluoromethoxy)phenyl]carbamoyl}amin...)
Affinity DataIC50: 5nMAssay Description:The enzyme also can be detected based on the binding of specific ligands to the catalytic site which either immobilize the enzyme or label it with a ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetEpoxide hydrolase 1(Dog)
The Regents of The University of California

US Patent
LigandPNGBDBM25741(4-{[4-({[4-(trifluoromethoxy)phenyl]carbamoyl}amin...)
Affinity DataIC50: 4nMAssay Description:The enzyme also can be detected based on the binding of specific ligands to the catalytic site which either immobilize the enzyme or label it with a ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetEpoxide hydrolase(Horse)
The Regents of The University of California

US Patent
LigandPNGBDBM25741(4-{[4-({[4-(trifluoromethoxy)phenyl]carbamoyl}amin...)
Affinity DataIC50: 29nMAssay Description:The enzyme also can be detected based on the binding of specific ligands to the catalytic site which either immobilize the enzyme or label it with a ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetEpoxide hydrolase(Sheep)
The Regents of The University of California

US Patent
LigandPNGBDBM25741(4-{[4-({[4-(trifluoromethoxy)phenyl]carbamoyl}amin...)
Affinity DataIC50: 6nMAssay Description:The enzyme also can be detected based on the binding of specific ligands to the catalytic site which either immobilize the enzyme or label it with a ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetEpoxide hydrolase 1(Cat)
The Regents of The University of California

US Patent
LigandPNGBDBM25741(4-{[4-({[4-(trifluoromethoxy)phenyl]carbamoyl}amin...)
Affinity DataIC50: 1nMAssay Description:The enzyme also can be detected based on the binding of specific ligands to the catalytic site which either immobilize the enzyme or label it with a ...More data for this Ligand-Target Pair
In DepthDetails
US Patent