BDBM255526 N4-(3-Methylcarbonyloximephenyl)-5-fluoro-N2-[3-(N-methylamino)carbonylmethyleneoxyphenyl]-2,4-pyrimidinediamine::US9499493, R950373

SMILES CNC(=O)COC1=C(C)CCC(Nc2ncc(F)c(Nc3cccc(c3)C(=O)NOC)n2)=C1

InChI Key InChIKey=GCKOKWAYKBKPAK-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 255526   

TargetTyrosine-protein kinase SYK(Human)
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM255526(N4-(3-Methylcarbonyloximephenyl)-5-fluoro-N2-[3-(N...)
Affinity DataIC50: 66.5nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
In DepthDetails
US Patent