BDBM255490 US10828301, Compound R935194::US9499493, R935194

SMILES Cn1ncc2cc(Nc3ncc(F)c(Nc4cccc(O)c4)n3)ccc12

InChI Key InChIKey=PENAQGMBLHBDLM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 255490   

TargetTyrosine-protein kinase SYK(Human)
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM255490(US9499493, R935194 | US10828301, Compound R935194)
Affinity DataIC50: 169nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2017
Entry Details
Go to US Patent

TargetTyrosine-protein kinase SYK(Human)
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM255490(US9499493, R935194 | US10828301, Compound R935194)
Affinity DataIC50: 169nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
Go to US Patent