BDBM254941 US10294259, Compound Table 3.2::US9505734, I-D1-6

SMILES CCOc1ccc(Cc2cc(ccc2Cl)C2OC(C)C(O)C(O)C2O)cc1

InChI Key InChIKey=YCEUTZKYUQXUCF-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 254941   

TargetSodium/glucose cotransporter 2(Human)
Tianjin Institute of Pharmaceutical Research

US Patent
LigandPNGBDBM254941(US9505734, I-D1-6 | US10294259, Compound Table 3.2)
Affinity DataIC50: 0.690nMAssay Description:The IC50 value of the inhibition of the cocrystal of I-D1-6 and L-proline prepared in Example 138 on SGLT2 and SGLT1 is measured according to the met...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2017
Entry Details
Go to US Patent

TargetSodium/glucose cotransporter 1(Human)
Tianjin Institute of Pharmaceutical Research

US Patent
LigandPNGBDBM254941(US9505734, I-D1-6 | US10294259, Compound Table 3.2)
Affinity DataIC50: 259nMAssay Description:The IC50 value of the inhibition of the cocrystal of I-D1-6 and L-proline prepared in Example 138 on SGLT2 and SGLT1 is measured according to the met...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2017
Entry Details
Go to US Patent

TargetSodium/glucose cotransporter 2(Human)
Tianjin Institute of Pharmaceutical Research

US Patent
LigandPNGBDBM254941(US9505734, I-D1-6 | US10294259, Compound Table 3.2)
Affinity DataIC50: 0.670nMAssay Description:IC50 values of inhibition of some compounds described in the present invention and related compounds on SGLT2 and SGLT1 are determined according to t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
Go to US Patent

TargetSodium/glucose cotransporter 1(Human)
Tianjin Institute of Pharmaceutical Research

US Patent
LigandPNGBDBM254941(US9505734, I-D1-6 | US10294259, Compound Table 3.2)
Affinity DataIC50: 251nMAssay Description:IC50 values of inhibition of some compounds described in the present invention and related compounds on SGLT2 and SGLT1 are determined according to t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
Go to US Patent