BDBM254940 US9499542, 23::US9675594, 23

SMILES Cc1cn(C)nc1Nc1cc(-c2ccnc(C)c2)c2c(c[nH]c2n1)C#N

InChI Key InChIKey=VXEOEBNYHYCSIR-UHFFFAOYSA-N

Data  6 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 254940   

LigandPNGBDBM254940(US9675594, 23 | US9499542, 23)
Affinity DataIC50: 108nMpH: 8.5 T: 2°CAssay Description:LRRK2 kinase activity is measured using a LanthaScreen kinase activity assay available from Invitrogen (Life Technologies Corporation). The assay is ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM254940(US9675594, 23 | US9499542, 23)
Affinity DataIC50: 215nMpH: 8.5 T: 2°CAssay Description:LRRK2 kinase activity is measured using a LanthaScreen kinase activity assay available from Invitrogen (Life Technologies Corporation). The assay is ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM254940(US9675594, 23 | US9499542, 23)
Affinity DataEC50:  108nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase is incubated with the test compound (typically at 0 to 30 μM) for 30 minutes before th...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM254940(US9675594, 23 | US9499542, 23)
Affinity DataEC50:  215nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase is incubated with the test compound (typically at 0 to 30 μM) for 30 minutes before th...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM254940(US9675594, 23 | US9499542, 23)
Affinity DataIC50: 215nMAssay Description:Inhibition of human wild type LRRK2 phosphorylation at ser935 transfected in HEK293 cells after 48 hrs by in-cell Western assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM254940(US9675594, 23 | US9499542, 23)
Affinity DataIC50: 215nMAssay Description:Inhibition of wild type recombinant human GST-tagged LRRK2 (970 to 2527 residues) expressed in baculovirus using fluorescein-LRRKtide as substrate af...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM254940(US9675594, 23 | US9499542, 23)
Affinity DataIC50: 210nMAssay Description:Inhibition of human LRRK2 G2019S mutant phosphorylation at ser935 expressed in BacMam transduced HEK293 cells after 48 hrs by in-cell Western assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM254940(US9675594, 23 | US9499542, 23)
Affinity DataIC50: 580nMAssay Description:Inhibition of human wild type LRRK2 phosphorylation at ser935 expressed in BacMam transduced HEK293 cells after 48 hrs by in-cell Western assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed