BDBM253422 US9458171, 382

SMILES C[C@@]1(CC[C@@H](CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(O)=O

InChI Key InChIKey=GCIQMJRRIADVCD-UHFFFAOYSA-N

Data  1 IC50  6 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 253422   

TargetNuclear receptor ROR-gamma [262-507](Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM253422(US9458171, 382)
Affinity DataIC50: 57nMT: 2°CAssay Description:The binding of potential ligands to RORγ is measured by competition with [3H] 25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintill...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2017
Entry Details
Go to US Patent

TargetOxysterols receptor LXR-beta(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM253422(US9458171, 382)
Affinity DataEC50: >7.50E+3nMAssay Description:Transactivation of human GAL4-fused LXRbeta expressed in African green monkey CV1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM253422(US9458171, 382)
Affinity DataEC50:  79nMAssay Description:Inverse agonist activity at human Gal4-fused RORgammat LBD (267 to 516 residues) expressed in human Jurkat cells measured after 18 hrs by steady-glo ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-alpha(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM253422(US9458171, 382)
Affinity DataEC50: >4.00E+4nMAssay Description:Inverse agonist activity at human Gal4-fused RORalpha LBD (272 to 556 residues) expressed in human Jurkat cells measured after 18 hrs by steady-glo l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM253422(US9458171, 382)
Affinity DataEC50: >7.50E+3nMAssay Description:Transactivation of human GAL4-fused LXRalpha expressed in African green monkey CV1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM253422(US9458171, 382)
Affinity DataEC50: >5.00E+4nMAssay Description:Transactivation of PXR (unknown origin) expressed in human HepG2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-beta(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM253422(US9458171, 382)
Affinity DataEC50: >4.00E+4nMAssay Description:Inverse agonist activity at human Gal4-fused RORbeta LBD (200 to 559 residues) expressed in human Jurkat cells measured after 18 hrs by steady-glo lu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed