BDBM25269 (1-hydroxy-1-phosphonodecyl)phosphonic acid::CHEMBL54004::bisphosphonate, 23

SMILES CCCCCCCCCC(O)(P(O)(O)=O)P(O)(O)=O

InChI Key InChIKey=NSCPCMXKWUFFNL-UHFFFAOYSA-N

Data  1 KI  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 25269   

TargetGeranylgeranyl pyrophosphate synthase(Human)
National Taiwan University

LigandPNGBDBM25269((1-hydroxy-1-phosphonodecyl)phosphonic acid | CHEM...)
Affinity DataIC50: 890nMpH: 7.0 T: 2°CAssay Description:The inhibitory activity of each test compound was evaluated by monitoring the formation of [14C]GGPP from FPP, using [14C]IPP as the substrate. To co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2008
Entry Details Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM25269((1-hydroxy-1-phosphonodecyl)phosphonic acid | CHEM...)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibitory activity against farnesyl Pyrophosphate Synthase was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGeranylgeranyl pyrophosphate synthase(Human)
National Taiwan University

LigandPNGBDBM25269((1-hydroxy-1-phosphonodecyl)phosphonic acid | CHEM...)
Affinity DataIC50: 720nMAssay Description:Inhibitory activity against the human recombinant geranylgeranyl diphosphate synthase (GGPPSase).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyprenyl synthetase family protein(Leishmania donovani)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM25269((1-hydroxy-1-phosphonodecyl)phosphonic acid | CHEM...)
Affinity DataIC50: 2.37E+3nMAssay Description:Inhibitory activity against Leishmania major Farnesyl diphosphate synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPhosphotransferase(Trypanosoma cruzi)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM25269((1-hydroxy-1-phosphonodecyl)phosphonic acid | CHEM...)
Affinity DataIC50: 2.75E+3nMAssay Description:Inhibitory activity against Trypanosoma cruzi hexokinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyprenyl synthetase family protein(Leishmania donovani)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM25269((1-hydroxy-1-phosphonodecyl)phosphonic acid | CHEM...)
Affinity DataIC50: 2.37E+3nMAssay Description:Inhibitory activity against FPPS in Leishmania majorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetH(+)-exporting diphosphatase(Trypanosoma brucei)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM25269((1-hydroxy-1-phosphonodecyl)phosphonic acid | CHEM...)
Affinity DataIC50: 3.57E+5nMAssay Description:Inhibition of recombinant Trypanosoma brucei soluble vacuolar pyrophosphatase expressed in Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM25269((1-hydroxy-1-phosphonodecyl)phosphonic acid | CHEM...)
Affinity DataIC50: 2.34E+3nMAssay Description:Inhibitory activity against farnesyl Pyrophosphate Synthase expressed as #NAME (M)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPhosphotransferase(Trypanosoma cruzi)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM25269((1-hydroxy-1-phosphonodecyl)phosphonic acid | CHEM...)
Affinity DataIC50: 810nMAssay Description:Inhibition of Trypanosoma cruzi hexokinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM25269((1-hydroxy-1-phosphonodecyl)phosphonic acid | CHEM...)
Affinity DataKi:  230nMAssay Description:Binding affinity towards farnesyl Pyrophosphate Synthase using [14C]- isopentenyl pyrophosphate as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed