BDBM25259 3-(decyloxy)-1-(2-hydrogen phosphonato-2-phosphonoethyl)pyridin-1-ium::Bisphpshonate-715::bisphosphonate, 15

SMILES CCCCCCCCCCOc1ccc[n+](CC(P(O)(O)=O)P(O)([O-])=O)c1

InChI Key InChIKey=QYJHUOZDBUEKQC-UHFFFAOYSA-N

Data  1 KI  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 25259   

TargetGeranylgeranyl pyrophosphate synthase(Human)
National Taiwan University

LigandPNGBDBM25259(Bisphpshonate-715 | 3-(decyloxy)-1-(2-hydrogen pho...)
Affinity DataIC50: 280nMpH: 7.0 T: 2°CAssay Description:The inhibitory activity of each test compound was evaluated by monitoring the formation of [14C]GGPP from FPP, using [14C]IPP as the substrate. To co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2008
Entry Details Article
PubMed
TargetGeranylgeranyl pyrophosphate synthase(Human)
National Taiwan University

LigandPNGBDBM25259(Bisphpshonate-715 | 3-(decyloxy)-1-(2-hydrogen pho...)
Affinity DataIC50: 2.50E+5nMAssay Description:Inhibition of human GGPPSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM25259(Bisphpshonate-715 | 3-(decyloxy)-1-(2-hydrogen pho...)
Affinity DataIC50: 100nMAssay Description:Inhibition of human FPPS using GPP and [3H]IPP as substrate by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetGeranylgeranyl pyrophosphate synthase(Human)
National Taiwan University

LigandPNGBDBM25259(Bisphpshonate-715 | 3-(decyloxy)-1-(2-hydrogen pho...)
Affinity DataIC50: 280nMAssay Description:Inhibition of human recombinant GGPS using [14C]-IPP as substrate incubated for 15 mins prior to substrate addition measured after 20 mins by scintil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM25259(Bisphpshonate-715 | 3-(decyloxy)-1-(2-hydrogen pho...)
Affinity DataIC50: 100nMAssay Description:Inhibition of human FPPS using FPP and [3H]-IPP as substrate incubated for 30 mins prior to substrate addition measured after 20 mins by scintillatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetGeranylgeranyl pyrophosphate synthase(Human)
National Taiwan University

LigandPNGBDBM25259(Bisphpshonate-715 | 3-(decyloxy)-1-(2-hydrogen pho...)
Affinity DataIC50: 280nMAssay Description:Inhibition of human recombinant GGPPS using [14C]-IPP as substrate incubated for 15 mins prior to substrate addition measured after 20 mins by scinti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM25259(Bisphpshonate-715 | 3-(decyloxy)-1-(2-hydrogen pho...)
Affinity DataIC50: 100nMAssay Description:Inhibition of human FPPS using IPP and GPPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetGeranylgeranyl pyrophosphate synthase(Human)
National Taiwan University

LigandPNGBDBM25259(Bisphpshonate-715 | 3-(decyloxy)-1-(2-hydrogen pho...)
Affinity DataIC50: 280nMAssay Description:Inhibition of human GGPPSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetGeranylgeranyl pyrophosphate synthase(Human)
National Taiwan University

LigandPNGBDBM25259(Bisphpshonate-715 | 3-(decyloxy)-1-(2-hydrogen pho...)
Affinity DataKi:  6.90E+3nMAssay Description:Inhibition of human GGPPSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed