BDBM252039 US9458110, 110

SMILES COc1cccc(c1)[C@@H](C)NC(=O)c1ccc(-c2cn[nH]c2)c(OC)c1F

InChI Key InChIKey=MQHAUPTVCAFIJM-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 252039   

TargetRho-associated protein kinase 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM252039(US9458110, 110)
Affinity DataIC50: 5.98nMpH: 7.5Assay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM252039(US9458110, 110)
Affinity DataIC50: 1.03nMpH: 7.5Assay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRho-associated protein kinase 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM252039(US9458110, 110)
Affinity DataIC50: 6nMAssay Description:Inhibition of ROCK1 (unknown origin) using FITC-AHA-AKRRRLSSLRA-OH peptide substrate by caliper assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM252039(US9458110, 110)
Affinity DataIC50: 1nMAssay Description:Inhibition of ROCK2 (unknown origin) using FITC-AHA-AKRRRLSSLRA-OH peptide substrate by caliper assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed