BDBM25191 4-{4-[(5-hydroxy-2-methylphenyl)amino]quinolin-7-yl}-1,3-thiazole-2-carbaldehyde::7-substituted 4-anilinoquinoline, 31::BMCL174363 Compound 1::BMCL18318 Compound 1

SMILES Cc1ccc(O)cc1Nc1ccnc2cc(ccc12)-c1csc(C=O)n1

InChI Key InChIKey=VKQPTVJDZIILPG-UHFFFAOYSA-N

Data  3 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 25191   

LigandPNGBDBM25191(BMCL18318 Compound 1 | 4-{4-[(5-hydroxy-2-methylph...)
Affinity DataIC50: 25nMpH: 7.4 T: 2°CAssay Description:The biochemical activity of compound was determined by incubation with Ret kinase and the substrate in the presence of ATP/ [gamma-33P] ATP. After in...More data for this Ligand-Target Pair
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LigandPNGBDBM25191(BMCL18318 Compound 1 | 4-{4-[(5-hydroxy-2-methylph...)
Affinity DataIC50: 59nMpH: 7.4 T: 2°CAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM25191(BMCL18318 Compound 1 | 4-{4-[(5-hydroxy-2-methylph...)
Affinity DataKi:  20nM ΔG°:  -10.4kcal/mole IC50: 59nMpH: 7.4 T: 2°CAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM25191(BMCL18318 Compound 1 | 4-{4-[(5-hydroxy-2-methylph...)
Affinity DataKi:  400nM ΔG°:  -8.63kcal/mole IC50: 2.50E+3nMpH: 7.5 T: 2°CAssay Description:Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM25191(BMCL18318 Compound 1 | 4-{4-[(5-hydroxy-2-methylph...)
Affinity DataKi: >4.00E+3nM ΔG°: >-7.28kcal/mole IC50: 1.60E+4nMpH: 7.5 T: 2°CAssay Description:Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed