BDBM25163 CHEMBL497332::N-methyl-N-(quinoxalin-6-ylmethyl)-5-(2,2,2-trifluoroacetyl)thiophene-2-carboxamide::thiophene derivative, 3i

SMILES CN(Cc1ccc2nccnc2c1)C(=O)c1ccc(s1)C(=O)C(F)(F)F

InChI Key InChIKey=RLNCISDDCDFAHS-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 25163   

TargetHistone deacetylase 1(Human)
Irbm/Merck Research Laboratories

LigandPNGBDBM25163(CHEMBL497332 | N-methyl-N-(quinoxalin-6-ylmethyl)-...)
Affinity DataIC50: 580nMpH: 8.0 T: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2008
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
Irbm/Merck Research Laboratories

LigandPNGBDBM25163(CHEMBL497332 | N-methyl-N-(quinoxalin-6-ylmethyl)-...)
Affinity DataIC50: 670nMT: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2008
Entry Details Article
PubMed
TargetHistone deacetylase 4 [653-1084,H976Y](Human)
Irbm/Merck Research Laboratories

LigandPNGBDBM25163(CHEMBL497332 | N-methyl-N-(quinoxalin-6-ylmethyl)-...)
Affinity DataIC50: 87nMT: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2008
Entry Details Article
PubMed
TargetHistone deacetylase 4(Human)
Irbm/Merck Research Laboratories

LigandPNGBDBM25163(CHEMBL497332 | N-methyl-N-(quinoxalin-6-ylmethyl)-...)
Affinity DataIC50: 98nMT: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2008
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Irbm/Merck Research Laboratories

LigandPNGBDBM25163(CHEMBL497332 | N-methyl-N-(quinoxalin-6-ylmethyl)-...)
Affinity DataIC50: 89nMT: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2008
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Irbm/Merck Research Laboratories

LigandPNGBDBM25163(CHEMBL497332 | N-methyl-N-(quinoxalin-6-ylmethyl)-...)
Affinity DataIC50: 580nMAssay Description:Inhibition of HDAC1 purified from HEK293 cells by Western blotMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
Irbm/Merck Research Laboratories

LigandPNGBDBM25163(CHEMBL497332 | N-methyl-N-(quinoxalin-6-ylmethyl)-...)
Affinity DataIC50: 670nMAssay Description:Inhibition of HDAC3 purified from HEK293 cells by Western blotMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Irbm/Merck Research Laboratories

LigandPNGBDBM25163(CHEMBL497332 | N-methyl-N-(quinoxalin-6-ylmethyl)-...)
Affinity DataIC50: 90nMAssay Description:Inhibition of HDAC6 purified from HEK293 cells by Western blotMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Irbm/Merck Research Laboratories

LigandPNGBDBM25163(CHEMBL497332 | N-methyl-N-(quinoxalin-6-ylmethyl)-...)
Affinity DataIC50: 580nMAssay Description:Inhibition of HDAC1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Irbm/Merck Research Laboratories

LigandPNGBDBM25163(CHEMBL497332 | N-methyl-N-(quinoxalin-6-ylmethyl)-...)
Affinity DataIC50: 89nMAssay Description:Inhibition of HDAC6More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed