BDBM251573 US9452998, Table 4 Compound 3

SMILES NC1CCN(CC1)c1ccccc1NC(=O)c1nc(cnc1N)-c1ccccc1

InChI Key InChIKey=JWHUZKCDLIXMSE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 251573   

TargetProtein kinase C alpha type(Human)
Novartis

US Patent
LigandPNGBDBM251573(US9452998, Table 4 Compound 3)
Affinity DataIC50: 0.150nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details
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TargetProtein kinase C theta type(Human)
Novartis

US Patent
LigandPNGBDBM251573(US9452998, Table 4 Compound 3)
Affinity DataIC50: 0.25nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details
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TargetGlycogen synthase kinase-3 beta(Human)
Novartis

US Patent
LigandPNGBDBM251573(US9452998, Table 4 Compound 3)
Affinity DataIC50: 1nMpH: 7.0 T: 2°CAssay Description:Types of GSK-3 assay used to test the selectivity/off target potential compounds of the invention with respect to PKC ±/ inhibition activity includes...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details
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TargetSerine/threonine-protein kinase pim-2(Human)
Novartis

US Patent
LigandPNGBDBM251573(US9452998, Table 4 Compound 3)
Affinity DataIC50: 770nMpH: 7.5Assay Description:For comparison between certain PKC inhibitors of the present application and structurally comparable PIM kinase inhibitors, the activity of PIM2 was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details
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