BDBM251507 US9452998, 56::US9452998, 76

SMILES NC1CCN(CC1)c1cccnc1NC(=O)c1nc(cnc1N)-c1cc(ccc1C(F)(F)F)N1CCOCC1

InChI Key InChIKey=OLYCNNWWUIENNA-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 251507   

TargetProtein kinase C alpha type(Human)
Novartis

US Patent
LigandPNGBDBM251507(US9452998, 76 | US9452998, 56)
Affinity DataIC50: 0.130nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details
Go to US Patent

TargetProtein kinase C alpha type(Human)
Novartis

US Patent
LigandPNGBDBM251507(US9452998, 76 | US9452998, 56)
Affinity DataIC50: 0.130nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details
Go to US Patent

TargetProtein kinase C theta type(Human)
Novartis

US Patent
LigandPNGBDBM251507(US9452998, 76 | US9452998, 56)
Affinity DataIC50: 0.880nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details
Go to US Patent

TargetProtein kinase C theta type(Human)
Novartis

US Patent
LigandPNGBDBM251507(US9452998, 76 | US9452998, 56)
Affinity DataIC50: 0.880nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details
Go to US Patent

TargetGlycogen synthase kinase-3 beta(Human)
Novartis

US Patent
LigandPNGBDBM251507(US9452998, 76 | US9452998, 56)
Affinity DataIC50: 6.50E+3nMpH: 7.0 T: 2°CAssay Description:Types of GSK-3 assay used to test the selectivity/off target potential compounds of the invention with respect to PKC ±/ inhibition activity includes...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details
Go to US Patent