BDBM251491 US9452998, 40::US9452998, 51

SMILES NC1CCN(CC1)c1cccnc1NC(=O)c1nc(cnc1N)-c1cccc(c1)N1CCOCC1

InChI Key InChIKey=YIAUOBNZXMZCFP-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 251491   

TargetProtein kinase C alpha type(Human)
Novartis

US Patent
LigandPNGBDBM251491(US9452998, 51 | US9452998, 40)
Affinity DataIC50: 0.130nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details
Go to US Patent

TargetProtein kinase C alpha type(Human)
Novartis

US Patent
LigandPNGBDBM251491(US9452998, 51 | US9452998, 40)
Affinity DataIC50: 0.200nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details
Go to US Patent

TargetProtein kinase C theta type(Human)
Novartis

US Patent
LigandPNGBDBM251491(US9452998, 51 | US9452998, 40)
Affinity DataIC50: 2.80nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details
Go to US Patent

TargetProtein kinase C theta type(Human)
Novartis

US Patent
LigandPNGBDBM251491(US9452998, 51 | US9452998, 40)
Affinity DataIC50: 1.5nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details
Go to US Patent