BDBM25139 2-cyano-pyrropyrimidine, 7e::7-[2-(4-chlorophenyl)ethyl]-6-[4-(4-acetylpiperazin-1-yl)phenoxymethyl]-7H-pyrrolo[2,3-d]pyrimidine-2-carbonitrile

SMILES CC(=O)N1CCN(CC1)c1ccc(OCc2cc3cnc(nc3n2CCc2ccc(Cl)cc2)C#N)cc1

InChI Key InChIKey=NOZGXEBRZYDFFQ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 25139   

TargetCathepsin S(Human)
Novartis

LigandPNGBDBM25139(7-[2-(4-chlorophenyl)ethyl]-6-[4-(4-acetylpiperazi...)
Affinity DataIC50: 17nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2008
Entry Details Article
PubMed
TargetCathepsin K(Human)
Novartis

LigandPNGBDBM25139(7-[2-(4-chlorophenyl)ethyl]-6-[4-(4-acetylpiperazi...)
Affinity DataIC50: 1.00E+3nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2008
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Novartis

LigandPNGBDBM25139(7-[2-(4-chlorophenyl)ethyl]-6-[4-(4-acetylpiperazi...)
Affinity DataIC50: 1.00E+3nMAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2008
Entry Details Article
PubMed