BDBM249561 US10072016, Compound 159::US10407433, Compound 159::US10913746, Compound 159::US11649240, Compound 159::US9434727, 159::US9777010, Compound 159

SMILES CS(=O)(=O)N1CCc2[nH]nc(C(=O)N3CCC(CC3)c3ccc(F)cc3C(F)(F)F)c2C1

InChI Key InChIKey=YKBRLQAQNFGOMR-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 249561   

TargetRetinol-binding protein 4(Human)
Columbia University

US Patent
LigandPNGBDBM249561(US9434727, 159 | US10072016, Compound 159 | US9777...)
Affinity DataIC50: 8.06nMpH: 7.4 T: 2°CAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2017
Entry Details
Go to US Patent

TargetRetinol-binding protein 4(Human)
Columbia University

US Patent
LigandPNGBDBM249561(US9434727, 159 | US10072016, Compound 159 | US9777...)
Affinity DataIC50: 52.3nMpH: 7.5 T: 2°CAssay Description:TR-FRET assay for retinol-induced RBP4-TTR interaction Binding of a desired RBP4 antagonist displaces retinol and induces hindrance for RBP4-TTR inte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2017
Entry Details
Go to US Patent

TargetRetinol-binding protein 4(Human)
Columbia University

US Patent
LigandPNGBDBM249561(US9434727, 159 | US10072016, Compound 159 | US9777...)
Affinity DataIC50: 8.06nMpH: 7.5Assay Description:Binding of a desired RBP4 antagonist displaces retinol and induces hindrance for RBP4-TTR interaction resulting in the decreased FRET signal (FIG. 7)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
Go to US Patent

TargetTransthyretin(Human)
Columbia University

US Patent
LigandPNGBDBM249561(US9434727, 159 | US10072016, Compound 159 | US9777...)
Affinity DataIC50: 52.3nMpH: 7.4 T: 2°CAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
Go to US Patent

TargetRetinol-binding protein 4(Human)
Columbia University

US Patent
LigandPNGBDBM249561(US9434727, 159 | US10072016, Compound 159 | US9777...)
Affinity DataIC50: 8.06nMAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2019
Entry Details
Go to US Patent

TargetRetinol-binding protein 4(Human)
Columbia University

US Patent
LigandPNGBDBM249561(US9434727, 159 | US10072016, Compound 159 | US9777...)
Affinity DataIC50: 8.06nMAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/27/2020
Entry Details
Go to US Patent

TargetRetinol-binding protein 4(Human)
Columbia University

US Patent
LigandPNGBDBM249561(US9434727, 159 | US10072016, Compound 159 | US9777...)
Affinity DataIC50: 8.06nMAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2021
Entry Details
Go to US Patent

TargetRetinol-binding protein 4(Human)
Columbia University

US Patent
LigandPNGBDBM249561(US9434727, 159 | US10072016, Compound 159 | US9777...)
Affinity DataIC50: 8.06nMAssay Description:The analogs of Compounds 63-162 described herein analogously bind to RBP4 and antagonize retinol-dependent RBP4-TTR interaction. Additional piperidin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
Go to US Patent

TargetRetinol-binding protein 4(Human)
Columbia University

US Patent
LigandPNGBDBM249561(US9434727, 159 | US10072016, Compound 159 | US9777...)
Affinity DataIC50: 52.3nMAssay Description:Binding of a desired RBP4 antagonist displaces retinol and induces hindrance for RBP4-TTR interaction resulting in the decreased FRET signal (FIG. 7 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
Go to US Patent