BDBM249559 US10072016, Compound 157::US10407433, Compound 157::US10913746, Compound 157::US11649240, Compound 157::US9434727, 157::US9777010, Compound 157

SMILES Fc1cccc(c1C1CCN(CC1)C(=O)c1nnc2ccc(cn12)C#N)C(F)(F)F

InChI Key InChIKey=SIRUQHYFMOSYSV-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 249559   

TargetRetinol-binding protein 4(Human)
Columbia University

US Patent
LigandPNGBDBM249559(US9434727, 157 | US10072016, Compound 157 | US9777...)
Affinity DataIC50: 5.84nMpH: 7.4 T: 2°CAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2017
Entry Details
Go to US Patent

TargetRetinol-binding protein 4(Human)
Columbia University

US Patent
LigandPNGBDBM249559(US9434727, 157 | US10072016, Compound 157 | US9777...)
Affinity DataIC50: 92.0nMpH: 7.5 T: 2°CAssay Description:TR-FRET assay for retinol-induced RBP4-TTR interaction Binding of a desired RBP4 antagonist displaces retinol and induces hindrance for RBP4-TTR inte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2017
Entry Details
Go to US Patent

TargetRetinol-binding protein 4(Human)
Columbia University

US Patent
LigandPNGBDBM249559(US9434727, 157 | US10072016, Compound 157 | US9777...)
Affinity DataIC50: 5.84nMpH: 7.5Assay Description:Binding of a desired RBP4 antagonist displaces retinol and induces hindrance for RBP4-TTR interaction resulting in the decreased FRET signal (FIG. 7)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
Go to US Patent

TargetTransthyretin(Human)
Columbia University

US Patent
LigandPNGBDBM249559(US9434727, 157 | US10072016, Compound 157 | US9777...)
Affinity DataIC50: 92nMpH: 7.4 T: 2°CAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
Go to US Patent

TargetRetinol-binding protein 4(Human)
Columbia University

US Patent
LigandPNGBDBM249559(US9434727, 157 | US10072016, Compound 157 | US9777...)
Affinity DataIC50: 5.84nMAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2019
Entry Details
Go to US Patent

TargetRetinol-binding protein 4(Human)
Columbia University

US Patent
LigandPNGBDBM249559(US9434727, 157 | US10072016, Compound 157 | US9777...)
Affinity DataIC50: 5.84nMAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/27/2020
Entry Details
Go to US Patent

TargetRetinol-binding protein 4(Human)
Columbia University

US Patent
LigandPNGBDBM249559(US9434727, 157 | US10072016, Compound 157 | US9777...)
Affinity DataIC50: 5.80nMAssay Description:Competitive displacement of 3[H]retinol from biotinylated RBP4 (unknown origin) by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetRetinol-binding protein 4(Human)
Columbia University

US Patent
LigandPNGBDBM249559(US9434727, 157 | US10072016, Compound 157 | US9777...)
Affinity DataIC50: 5.84nMAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2021
Entry Details
Go to US Patent

TargetRetinol-binding protein 4(Human)
Columbia University

US Patent
LigandPNGBDBM249559(US9434727, 157 | US10072016, Compound 157 | US9777...)
Affinity DataIC50: 5.84nMAssay Description:The analogs of Compounds 63-162 described herein analogously bind to RBP4 and antagonize retinol-dependent RBP4-TTR interaction. Additional piperidin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
Go to US Patent

TargetRetinol-binding protein 4(Human)
Columbia University

US Patent
LigandPNGBDBM249559(US9434727, 157 | US10072016, Compound 157 | US9777...)
Affinity DataIC50: 92nMAssay Description:Binding of a desired RBP4 antagonist displaces retinol and induces hindrance for RBP4-TTR interaction resulting in the decreased FRET signal (FIG. 7 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
Go to US Patent