BDBM249346 US10300060, Example 21-67::US10765676, Example 21-67::US9463192, 21-67::US9763943, 21-67::US9993479, 21-67

SMILES CCNc1ccn2ncc(-c3ccc(Oc4ncc(NC(=O)Nc5cc(ccc5-c5cccc(C)c5)C(F)(F)F)cn4)cc3)c2n1

InChI Key InChIKey=GBAMXTSXBYEWGV-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 249346   

TargetHigh affinity nerve growth factor receptor(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM249346(US9463192, 21-67 | US9763943, 21-67 | US9993479, 2...)
Affinity DataIC50: 4nMT: 2°CAssay Description:On the day before the assay, CellSenser TrkA-NFAT-bla CHO-K1 cells were suspended in an assay medium (Opti-MEM1 Reduced Serum Medium (Invitrogen) con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2017
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM249346(US9463192, 21-67 | US9763943, 21-67 | US9993479, 2...)
Affinity DataIC50: 4nMAssay Description:On the day before the assay, CellSenser TrkA-NFAT-bla CHO-K1 cells were suspended in an assay medium (Opti-MEM1 Reduced Serum Medium (Invitrogen) con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2019
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM249346(US9463192, 21-67 | US9763943, 21-67 | US9993479, 2...)
Affinity DataIC50: 4nMAssay Description:TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2020
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM249346(US9463192, 21-67 | US9763943, 21-67 | US9993479, 2...)
Affinity DataIC50: 4nMAssay Description:On the day before the assay, CellSenser TrkA-NFAT-b1a CHO-K1 cells were suspended in an assay medium (Opti-MEM1 Reduced Serum Medium (Invitrogen) con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM249346(US9463192, 21-67 | US9763943, 21-67 | US9993479, 2...)
Affinity DataIC50: 4nMAssay Description:On the day before the assay, CellSenser TrkA-NFAT-bla CHO-K1 cells were suspended in an assay medium (Opti-MEM1 Reduced Serum Medium (Invitrogen) con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
Go to US Patent