BDBM249171 US9453048, 13::US9453048, 15

SMILES CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@H](CC1C(=O)N[C@@H]1CCCc2ccccc12)NC(=O)c1ccc(COc2ccc(CN(NC(=O)[C@H](C)NC)C(=O)C3CCC[C@H]3C(=O)NC3CCCc4ccccc34)cc2)cc1)C(C)(C)C

InChI Key InChIKey=PCTAIOPAYXJDHB-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 249171   

TargetE3 ubiquitin-protein ligase XIAP [241-356](Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM249171(US9453048, 13 | US9453048, 15)
Affinity DataIC50: 0.150nMT: 2°CAssay Description:Assays were performed in black, flat-bottom, 384-well plates. The final assay volume was 50 μL prepared from additions of N-His-Tb-BIR3(241-356,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2017
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase XIAP [241-356](Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM249171(US9453048, 13 | US9453048, 15)
Affinity DataIC50: 0.230nMT: 2°CAssay Description:Assays were performed in black, flat-bottom, 384-well plates. The final assay volume was 50 μL prepared from additions of N-His-Tb-BIR3(241-356,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2017
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase XIAP [124-240](Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM249171(US9453048, 13 | US9453048, 15)
Affinity DataIC50: 2.43nMT: 2°CAssay Description:Assays were performed in white, flat-bottom, 384-well ProxiPlates (Perkin Elmer). The final assay volume was 10 μL prepared from additions of Hi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2017
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase XIAP [124-240](Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM249171(US9453048, 13 | US9453048, 15)
Affinity DataIC50: 2nMT: 2°CAssay Description:Assays were performed in white, flat-bottom, 384-well ProxiPlates (Perkin Elmer). The final assay volume was 10 μL prepared from additions of Hi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2017
Entry Details
Go to US Patent