BDBM248056 1-(2,3-dihydro-1,4-benzodioxin-5-yl)-4-[[5-(4-fluorophenyl)pyridin-3-yl]methyl]piperazine::Adoprazine

SMILES Fc1ccc(cc1)-c1cncc(CN2CCN(CC2)c2cccc3OCCOc23)c1

InChI Key InChIKey=IUVSEUFHPNITEQ-UHFFFAOYSA-N

Data  15 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 248056   

Target5-hydroxytryptamine receptor 1A(Human)
Pierre Fabre Research Center

Curated by ChEMBL
LigandPNGBDBM248056(Adoprazine | 1-(2,3-dihydro-1,4-benzodioxin-5-yl)-...)
Affinity DataEC50:  5.90nMAssay Description:Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Pierre Fabre Research Center

Curated by ChEMBL
LigandPNGBDBM248056(Adoprazine | 1-(2,3-dihydro-1,4-benzodioxin-5-yl)-...)
Affinity DataKi:  0.794nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Pierre Fabre Research Center

Curated by ChEMBL
LigandPNGBDBM248056(Adoprazine | 1-(2,3-dihydro-1,4-benzodioxin-5-yl)-...)
Affinity DataKi:  0.794nMAssay Description:Displacement of [3H]8-OH-DPAT from recombinant human 5HT1A receptor expressed in CHO cell membrane measured after 60 mins by scintillation counting m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Pierre Fabre Research Center

Curated by ChEMBL
LigandPNGBDBM248056(Adoprazine | 1-(2,3-dihydro-1,4-benzodioxin-5-yl)-...)
Affinity DataKi:  2.30nMAssay Description:Displacement of [3H]OH-DPAT from rat cortex 5HT1A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM248056(Adoprazine | 1-(2,3-dihydro-1,4-benzodioxin-5-yl)-...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]spiperone from human dopamine D2 receptor short form expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM248056(Adoprazine | 1-(2,3-dihydro-1,4-benzodioxin-5-yl)-...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Pierre Fabre Research Center

Curated by ChEMBL
LigandPNGBDBM248056(Adoprazine | 1-(2,3-dihydro-1,4-benzodioxin-5-yl)-...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]YM-09151-2 from rat striatum D2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM248056(Adoprazine | 1-(2,3-dihydro-1,4-benzodioxin-5-yl)-...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]spiperone from recombinant human D2S receptor expressed in CHO cell membrane measured after 60 mins by scintillation counting met...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM248056(Adoprazine | 1-(2,3-dihydro-1,4-benzodioxin-5-yl)-...)
Affinity DataKi:  8.40nM ΔG°:  -11.0kcal/molepH: 7.4 T: 2°CAssay Description:Human-cloned dopamine D2L receptors stably expressed in C6 rat glioma cells (kindly donated by Professor Roberto Maggio, Università di L'Aquil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2017
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Pierre Fabre Research Center

Curated by ChEMBL
LigandPNGBDBM248056(Adoprazine | 1-(2,3-dihydro-1,4-benzodioxin-5-yl)-...)
Affinity DataKi:  8.64nM ΔG°:  -11.4kcal/molepH: 7.4 T: 2°CAssay Description:Human-cloned 5-HT1A serotonin receptors stably expressed in HEK293-EBNA cells (Perkin-Elmer, Waltham, MA) were radiolabeled with 1.0nM [3H]-8-OH-DPAT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2017
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM248056(Adoprazine | 1-(2,3-dihydro-1,4-benzodioxin-5-yl)-...)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]spiperone from human dopamine D4.4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM248056(Adoprazine | 1-(2,3-dihydro-1,4-benzodioxin-5-yl)-...)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM248056(Adoprazine | 1-(2,3-dihydro-1,4-benzodioxin-5-yl)-...)
Affinity DataKi:  63nMAssay Description:Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM248056(Adoprazine | 1-(2,3-dihydro-1,4-benzodioxin-5-yl)-...)
Affinity DataKi:  251nMAssay Description:Displacement of [3H]ketanserin from human 5HT2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM248056(Adoprazine | 1-(2,3-dihydro-1,4-benzodioxin-5-yl)-...)
Affinity DataKi:  501nMAssay Description:Displacement of [3H]prazosin from adrenergic alpha1 receptor in rat cerebral cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Pierre Fabre Research Center

Curated by ChEMBL
LigandPNGBDBM248056(Adoprazine | 1-(2,3-dihydro-1,4-benzodioxin-5-yl)-...)
Affinity DataKi:  724nMAssay Description:Displacement of [3H]ketanserin from rat cortex 5HT2A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed