BDBM24716 Tetrahydropyrazolo[3,4-a]carbazole, 25::ethyl 3,4,16-triazatetracyclo[7.7.0.0^{2,6}.0^{10,15}]hexadeca-1(9),2,5,10,12,14-hexaene-5-carboxylate

SMILES CCOC(=O)c1[nH]nc-2c1CCc1c-2[nH]c2ccccc12

InChI Key InChIKey=QHWAAKZCUILDML-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 24716   

TargetAurora kinase A(Human)
Genentech

LigandPNGBDBM24716(ethyl 3,4,16-triazatetracyclo[7.7.0.0^{2,6}.0^{10,...)
Affinity DataIC50: 5.70E+3nMpH: 7.5 T: 2°CAssay Description:Aurora kinase was assayed in ELISA format using a GST fusion of the N-terminus of Histone H3 as substrate. Plates were coated with substrate, and the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2008
Entry Details Article
PubMed
LigandPNGBDBM24716(ethyl 3,4,16-triazatetracyclo[7.7.0.0^{2,6}.0^{10,...)
Affinity DataEC50:  4.86E+3nMAssay Description:Inhibition of RIP1/JNK2 (unknown origin)-mediated necrosisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed