BDBM24713 1,2,4,5-tetrahydropyrazolo[3,4-a]carbazole::3,4,16-triazatetracyclo[7.7.0.0^{2,6}.0^{10,15}]hexadeca-1(9),2,5,10,12,14-hexaene::Tetrahydropyrazolo[3,4-a]carbazole, 19

SMILES C1Cc2c([nH]c3ccccc23)-c2n[nH]cc12

InChI Key InChIKey=WQSHEPAFFTVLAP-UHFFFAOYSA-N

Data  5 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 24713   

TargetAurora kinase A(Human)
Genentech

LigandPNGBDBM24713(3,4,16-triazatetracyclo[7.7.0.0^{2,6}.0^{10,15}]he...)
Affinity DataIC50: 300nMpH: 7.5 T: 2°CAssay Description:Aurora kinase was assayed in ELISA format using a GST fusion of the N-terminus of Histone H3 as substrate. Plates were coated with substrate, and the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2008
Entry Details Article
PubMed
TargetFocal adhesion kinase 1(Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM24713(3,4,16-triazatetracyclo[7.7.0.0^{2,6}.0^{10,15}]he...)
Affinity DataIC50: 8.52E+3nMAssay Description:Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2011
Entry Details
PCBioAssay
TargetMitogen-activated protein kinase 10(Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM24713(3,4,16-triazatetracyclo[7.7.0.0^{2,6}.0^{10,15}]he...)
Affinity DataIC50: 2.06E+4nMAssay Description:Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: The Scripps Research Institute, TSRI Assay Provide...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2011
Entry Details
PCBioAssay
TargetProtein-tyrosine kinase 2-beta(Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM24713(3,4,16-triazatetracyclo[7.7.0.0^{2,6}.0^{10,15}]he...)
Affinity DataIC50: 1.05E+4nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2011
Entry Details
PCBioAssay
TargetSerine/threonine-protein kinase 33(Human)
Broad Institute

Curated by PubChem BioAssay
LigandPNGBDBM24713(3,4,16-triazatetracyclo[7.7.0.0^{2,6}.0^{10,15}]he...)
Affinity DataEC50:  6.10E+4nMAssay Description:Keywords: STK33 Kinase, Non-ATP Competitive Inhibitor Assay Overview: Purified STK33 Kinase is preincubated with potential inhibitors and allowed to ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2011
Entry Details
PCBioAssay
TargetMethionine--tRNA ligase(Trypanosoma brucei brucei (strain 927/4 GUTat10.1))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM24713(3,4,16-triazatetracyclo[7.7.0.0^{2,6}.0^{10,15}]he...)
Affinity DataIC50: 5.21E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2013
Entry Details
PCBioAssay
LigandPNGBDBM24713(3,4,16-triazatetracyclo[7.7.0.0^{2,6}.0^{10,15}]he...)
Affinity DataEC50:  500nMAssay Description:Inhibition of RIP1/JNK2 (unknown origin)-mediated necrosisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed