BDBM247046 2-((1R,3aR,6S, 7R,7aS)-7-((E)- 2- (2'-cyano-[3,3'- bipyridin]-6- yl)vinyl)-5,5- difluoro-1,6- dimethyl-3- oxooctahydro- isobenzofuran- 3a- yl)acetamide::US9701669, 17

SMILES C[C@H]1OC(=O)[C@]2(CC(N)=O)CC(F)(F)[C@@H](C)[C@H](\C=C\c3ccc(cn3)-c3cccnc3C#N)[C@H]12

InChI Key InChIKey=JRBNEHYNSKWJMK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 247046   

TargetSerine/threonine-protein kinase MARK2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM247046(2-((1R,3aR,6S, 7R,7aS)-7-((E)- 2- (2'-cyano-[3...)
Affinity DataIC50: 21.2nMAssay Description:This assay measures the potency of the inventive compounds as PAR-1 receptor antagonists.Frozen HEK 293 Cells were plated in 384-well PDL coated plat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
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TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM247046(2-((1R,3aR,6S, 7R,7aS)-7-((E)- 2- (2'-cyano-[3...)
Affinity DataIC50: 2.19E+4nMpH: 7.4 T: 2°CAssay Description:Drug cardiac arrhythmia is an important safety concern for pharmaceutical development and health regulatory authorities. Blockade of heterologously-e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
Go to US Patent